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I'm wondering if its possible to do negative regular expressions (my attempt at ?! groups didn't work). i.e. find all posts that don't have a yEnc in them.

You can make a filter profile apply "yenc" as a "Subject Reject" filter then when you want to show only posts with no "yenc" apply the filter profile. It'll then hide all posts with "yEnc" in the subject.

yes, I figured that out, just thought there might be value to negative regular expressions as well.